Name: Tung-Hu Tsai, Ph.D.
Current Position: President, National United University, Miaoli, Taiwan
Address:
2, Lienda, Miaoli 36063, Taiwan
Tel: (886-37) 381011
Fax: (886-37) 381019
E-mail: thtsai@nuu.edu.tw

Educations:
Department of Chemical Engineering, National United University, Taiwan
B.S. Department of Pharmacy, Taipei Medical University, Taiwan 
M.S. Institute of Pharmacology, National Yang-Ming University, Taiwan 
Ph.D. Institute of Pharmacology, National Yang-Ming University, Taiwan 
Post doctoral Research Fellow, Department of Experimental Psychology, Cambridge University, England, UK

Professional Position/Experience:

2011 - 2015 Director, Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
2010/8 - 2010/12, Associate Dean, Office of International Affairs, National Yang-Ming University, Taipei, Taiwan
2009 – 2015 Director, Institute of Traditional Medicine, National Yang-Ming University
2002 - Professor, Institute of Traditional Medicine, National Yang-Ming University
1999 - 2005 Chief, Division of Chinese Medicine and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan
1995 - 2002 Associate Professor, Institute of Traditional Medicine, National Yang-Ming University
1994 - 1999 Associate Research Fellow, Division of Chinese Medicine and Natural Products, National Research Institute of Chinese Medicine, Taiwan
1989 - 1994 Assistant Research Fellow, Division of Chinese Medicine and Natural Products, National Research Institute of Chinese Medicine, Taiwan

Chief Editor and Editorial Board:
Editor, John Wiley & Sons, Inc. the book of Application of Microdialysis in Pharmaceutical Science 
Editorial Board, Journal of Pharmaceutical and Biomedical Analysis (SCI) 
Editorial Board, Biomedical Chromatography (SCI) 
Editorial Board, International Journal of Gerontology (SCI) 
Editorial Board, Journal of Chromatography B (SCI) 

Honor and Awards:
1995-2001 Research Awards, National Science Council, Taiwan 
Top referee 2007, Journal of Pharmaceutical and Biomedical Analysis 
Top referee 2008, Journal of Chromatography B 
2008, 2016 Award for excellence in teaching, National Yang-Ming University 
2007-2009 Award for outstanding in research, National Yang-Ming University 
2009 Most-Cited Articles listed are based on data from Thomson Reuters®. 
2009-2010 Award for outstanding in research, National Yang-Ming University

Scientific Commitment:
Reviewer of Scientific Journals (SCI):
1. African Journal of Pharmacy and Pharmacology
2. The American Journal of Chinese Medicine
3. Analytica Chimica Acta
4. Autonomic Neuroscience
5. Biomedical Engineering
6. British Journal of Pharmacology
7. Cancer Biotherapy & Radiopharmaceuticals
8. Chromatographia
9. Colloids and Surfaces B: Biointerfaces 
10. Current Pharmaceutical Analysis
11. European Journal of Pharmaceutical Science
12. Expert Opinion On Drug Metabolism and Toxicology
13. International Journal of Pharmaceutics
14. Journal of Agriculture Food and Chemistry
15. Journal of Biochemical and Biophysical Methods
16. Journal of Biomedical Nanotechnology
17. Journal of Chromatography A
18. Journal of Chromatography B
19. Journal of Medicinal Plants Research
20. Journal of Natural Products
21. Journal of Orthopaedic Surgery and Research
22. Journal of Pharmacy and Pharmacology
23. Journal of Pharmaceutical and Biomedical Analysis
24. Journal of Pharmaceutical Sciences
25. Journal of Separation Science
26. Journal of Traditional and Complementary Medicine;
27. Journal of Zhejiang University-SCIENCE B.
28. Life Sciences
29. Methods and Findings in Experimental and Clinical Pharmacology
30. Molecular Nutrition and Food Research
31. Molecules
32. Nutrition Research
33. Planta Medica
34. PlosOne;
35. Pharmaceutical Research
36. Pharmacological Report
37. Phytochemical Analysis
38. Rapid Communications in Mass Spectrometry
39. Regulatory Toxicology and Pharmacology
40. Research in Veterinary Science
41. Talanta　

Assessor of Project Grants for the following funding organizations:
National Science Council (Taiwan) 
National Research Institute of Chinese Medicine (Taiwan) 
Taipei Veterans General Hospital (Taiwan) 
Taipei Medical University (Taiwan) 
Hong Kong Research Grants Council oversea reviewer (Hong Kong) 
Austria Research Grants oversea reviewer (Austria)

Professional Societies:
The Pharmacological Society in Taiwan
The Society of Chinese Natural Medicine, Taiwan
The Society of Taiwan Pharmaceutical Science, Taiwan

PUBLICATIONS (REFEREE PAPER)
1. Tsai, T.H., Chen, C.F. (1991) Determination of three active principles in licorice extract by reversed-phase high-performance liquid Chromatography. Journal of Chromatography. 542:521-525. (SCI)
2. Tsai, T.H., Chen, C.F. (1991) High-performance liquid chromatographic determination of 18-alpha-glycyrrhetinic acid and 18-beta-glycyrrhetinic acid in rat plasma: application to pharmacokinetic study. Journal of Chromatography. 567:405-414. (SCI)
3. Tsai, T.H., Chen, C.F. (1991) Atlas of Chromatograms of glycyrrhizin, 18-alpha-glycyrrhetinic acid and 18-beta-glycyrrhetinic acid from licorice. Journal of Chromatography Science. 29:368. (SCI)
4. Tsai, T.H., Chen, C.M., Chen, C.F. (1992) Disposition of asarone after intravenous administration to rabbits assessed using HPLC. Journal of Pharmacy and Pharmacology. 44:620-623. (SCI)
5. Tsai, T.H., Liao, J.F., Yang, H.Y., Chen, C.F. (1992) Effects of licorice and its active principles on carrageenan-induced edema of the rat hind-paw. Journal of Chinese Medicine. 3:33-39.
6. Tsai, T.H., Chen, C.F. (1992) Ultraviolet spectrum identification of ferulic acid in rabbit plasma by HPLC and its pharmacokinetics application. International Journal Pharmaceutics. 80: 75-79. (SCI)
7. Tsai, T.H., Chen, C.F. (1992) Ultraviolet spectrum identification of emodin in rabbit plasma by HPLC and its pharmacokinetics application. Asia Pacific Journal of Pharmacology. 7: 53-56. (SCI)
8. Tsai, T.H., Chen, C.F. (1992) Determination of glycyrrhizin in rabbit plasma by high-performance liquid chromatography with photodiode-array ultraviolet detection and its pharmacokinetics application. Journal of Chromatography. 576: 170-173. (SCI)
9. Tsai, T.H., Chen, C.F. (1992) Identification and determination of honokiol and magnolol from Magnolia officinalis by high-performance liquid chromatography with photodiode-array UV detection. Journal of Chromatography. 598: 143-146. (SCI)
10. Tsai, T.H., Liao, J.F., Shum A.Y.C., Chen, C.F. (1992) Pharmacokinetics of glycyrrhizin after intravenous administration to rats. Journal of Pharmaceutical Sciences. 81: 961-963. (SCI)
11. Tsai, T.H., Shen, C.C., Chen, C.F. (1992) Determination and ultraviolet spectrum identification of 18-α-glycyrrhetinic acid and 18-β-glycyrrhetinic acid for stability studies. International Journal of Pharmaceutics. 84: 279-281. (SCI)
12. Tsai, T.H., Chou, C.J., Lin, L.C., Tsai, W.J., Chen, C.F. (1993) Determination of aristolochic acid in rabbit plasma by high-performance liquid chromatography with photodiode array ultraviolet detection and its pharmacokinetics application. Journal of Liquid Chromatography. 16: 1173-1182. (SCI)
13. Peng, Y.T., Shum, A.Y.C., Tsai, T.H., Lin, L.C., Chen, C.F. (1993) High-performance liquid chromatography of the quinazolinocarboline alkaloid dehydroevodiamine. Journal of Chromatography. 617: 87-93. (SCI)
14. Tsai, T.H., Chen, C.F. (1994) Simultaneous measurement of acetylcholine and monoamines by two serial on-line microdialysis systems: effects of methamphetamine on neurotransmitters release from the striatum of freely moving rats. Neuroscience Letters. 166: 175-177. (SCI)
15. Tsai, T.H., Westly, J., Lee, T.F., Chen, C.F. (1994) Identification and determination of geniposide, genipin, gardenoside and geniposidic acid form herbs by HPLC/photodiode-array detection. Journal of Liquid Chromatography. 17: 2199-2205. (SCI)
16. Cheng, F.C., Kuo, J.S., Chia, L.G., Tsai, T.H., Chen, C.F. (1994) Rapid measured of the monoamine content in small volumes of rat plasma. Journal of Chromatography B. 654: 177-183. (SCI)
17. Tsai, T.H., Chou, C.J., Cheng, F.C., Chen, C.F. (1994) Pharmacokinetics of honokiol after intravenous administration in rats assessed using high-performance liquid chromatography. Journal of Chromatography B. 655: 41-45. (SCI)
18. Ko, H.C., Tsai, T.H., Chou, C.J., Hsu, S.Y., Li, S.Y., Chen, C.F. (1994) High-performance liquid chromatographic determination of rutaecarpine in rat plasma: application to pharmacokinetic study. Journal of Chromatography B. 655: 27-31. (SCI)
19. Tsai, T.H., Chou, C.J., Chen, C.F. (1994) Disposition of magnolol after intravenous bolus and infusion in rabbit. Drug Metabolism and Disposition. 22: 518-521. (SCI)
20. Tsai, T.H., Chou, C.J., Chen, C.F. (1994) Pharmacokinetics of paeonol after intravenous administration to rats. Journal of Pharmaceutical Sciences. 83: 1307-1309. (SCI)
21. Lee, T.F., Tsai, T.H., Chen, C.F., Wang, L.C.H. (1994) Thermoregulatory effects after intracerebroventricular injections of wu-chu-yu extracts in rats. Thermal Balance in Health and Disease. 136: 481-484.
22. Tsai, T.H., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Thermoregulatory effects of alkaloids isolated from wu-chu-yu in afebrile and febrile rats. Pharmacology Biochemistry and Behavior. 50: 293-298. (SCI)
23. Shyr, M.H., Tsai, T.H., Tan, P.P.C., Chen, C.F., Chan, S.H.H. (1995) Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat. Neuroscience Letters. 184: 212-215. (SCI)
24. Tsai, T.H., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Modulatory effects of magnolol on potassium stimulated 5-HT release from rat cortical and hippocampal slices. Neuroscience Letters. 186: 49-52. (SCI)
25. Tsai, T.H., Tsai, W.J., Chou, C.J., Chen, C.F. (1995) Magnolol inhibits collagen-induced platelet serotonin release. Thrombosis Research. 78: 265-270. (SCI)
26. Tsai, T.H., Tsai, W.J., Chou, C.J., Chen, C.F. (1995) Inhibition by honokiol of collagen-induced platelet 5-HT release. Pharmaceutical Sciences. 1: 243-245.
27. Tsai, T.H., Chou, C.J., Chen, C.M., Chen, C.F. (1995) Determination of magnolol in rat plasma by HPLC/fluorescence. Chinese Pharmaceutical Journal. 47:207-212.
28. Jeng, K.F., Lin, Y.H., Lin, L.C., Chou, C.J., Tsai, T.H., Chen, C.F. (1995) High-performance liquid chromatographic determination of evodiamine in rats plasma: application to pharmacokinetic study. Journal of Chromatography B. 668: 343-345. (SCI)
29. Tsai, T.H., Tsai, W.J., Chen, C.F. (1995) Aspirin inhibits collagen-induced platelet serotonin, measured by microbore high-performance liquid chromatography electrochemical detection. Journal of Chromatography B. 669: 404-407. (SCI)
30. Tsai, T.H., Westly, J., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Effects of honokiol and magnolol on acetylcholine and norepinephrine from rat hippocampal slices. Planta Medica. 61: 477-479. (SCI)
31. Tsai, T.H., Chou, C.J., Chen, C.F. (1995) Glucuronidation of magnolol assessed using HPLC/fluorescence. Planta Medica. 61: 491-492. (SCI)
32. Chang, A.Y.W., Kuo, T.B.J., Tsai, T.H., Chen, C.F., Chan, S.H.H. (1995) Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex. Synapse. 21: 149-157. (SCI)
33. Tsai, T.H., Chou, C.J., Chen, C.F. (1996) Pharmacokinetic and brain distribution of magnolol in the rats after intravenous bolus injection. Journal of Pharmacy and Pharmacology. 48: 57-59. (SCI)
34. Tsai, T.H.*, Chou, C.J., Tsai, W.J., Chen, C.F. (1996) Magnolol inhibits arachidonic acid-induced rabbit platelet serotonin release, measure by microbore HPLC with electrochemical detection. Journal of Liquid Chromatography. 19: 949-955. (SCI)
35. Tsai, T.H.*, Hsu, S.Y., Chou, C.J., Tsai, T.R., Chen, C.F. (1996) Determination of dihydro-5,6-dehydrokawain in rat plasma by HPLC and its pharmacokinetics application. Journal of Liquid Chromatography. 19: 1127-1137. (SCI)
36. Tsai, T.H., Chen, C.F. (1996) An in vivo microdialysis determination of collagen-induced serotonin release in rat blood. Journal of Chromatography A. 730: 121-123. (SCI)
37. Wang, H., Kuo, T.B.S., Chan, S.H.H. Tsai, T.H., Lee, T.Y., Lui, P.W. (1996) Spectral analysis of arterial pressure variability during induction of propofol anesthesia. Anesthesia and Analgesia. 82: 914-919. (SCI)
38. Tsai, T.R., Cham, T.M., Chen, K.C., Chen, C.F., Tsai, T.H.* (1996) Determination of acetylcholine by on-line microdialysis coupled with pre- and post-microbore column enzyme reactors with electrochemical detection. Journal of Chromatography B. 678: 151-155. (SCI)
39. Tsai, T.H.*, Tsai, T.R., Chen, C.C., Chen, C.F. (1996) Determination of osthole in rat plasma by HPLC and its pharmacokinetics application. Journal of Pharmaceutical and Biomedical Analysis. 14: 749-753. (SCI)
40. Tsai, T.H.*, Tsai, T.R., Chou, C.J., Chen, C.F. (1996) Determination of dicentrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetics. Journal of Chromatography B. 681:277-281. (SCI)
41. Tsai, T.H.*, Chou, C.J., Tsai, T.R., Chen, C.F. (1996) Determination of wogonin in rat plasma by HPLC and its Pharmacokinetics application. Planta Medica. 62:263-266. (SCI)
42. Chou, C.Y.C., Tsai, T.H., Lin, M.F., Chen, C.F. (1996) Simultaneous determination of honokiol and magnolol in Magnolia officinalis by capillary zone electrophoresis. Journal of Liquid Chromatography. 19:1909-1915. (SCI)
43. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1996) Determination of triacylglycerols in Panax pseudo-ginseng by HPLC polymeric column. Journal of Liquid Chromatography. 19:2497-2503. (SCI)
44. Tsai, T.H.*, Kuo, K.W., Cheng, F.C., Chen, C.F. (1996) Determination of scoparone in rat plasma by liquid chromatography and it application to pharmacokinetics. Journal of Liquid Chromatography. 19:2649-2657. (SCI)
45. Tsai, T.H.* (1996) The technology and pharmaceutical analysis microbore column liquid chromatography. Chemistry. 54:111-117.
46. Tsai, T.H.*, Chou, C.J., Lee, T.F., Wang, L.C.H., Chen, C.F. (1996) Pharmacokinetic and pharmacodynamic studies of magnolol after oral administration in rats. Pharmaceutical Sciences. 2:191-193. 
47. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1996) Determination of trilinolein in the vasoactive and antithrombotic herbs by HPLC. Journal of Chinese Medicine. 7:203-210. 
48. Tsai, T.H.*, Chen, C.F., Cheng, F.C., Kuo, K.W., Tsai, T.R. (1997) Analysis and pharmacokinetics of apomorphine in rat brain by microdialysis coupled with microbore HPLC electrochemical detection. Journal of Liquid Chromatography. 20:481-490. (SCI)
49. Tsai, T.H.*, Chen, C.F. (1997) Measurement and pharmacokinetic analysis of buspirone brain microdialysis coupled with electrochemical detection. Journal of Chromatography A. 762:269-273. (SCI)
50. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1997) Determination of trilinolein and 1,2-dilinoleoyl-3-oleoyl-glycerol in various Panax ginseng by HPLC. Journal of Liquid Chromatography. 20:899-905. (SCI)
51. Tsai, T.H.*, Matthews, C.A., Chen, C.F. (1997) Aromatherapy. Journal of Chinese Medicine. 8:23-32. 
52. Huang, S.S., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1997) Identification of magnolol and honokiol in the stem and leave of Magnolia gradiflora L. and Magnolia coco (Lour.) DC. by liquid chromatography. Journal of Chinese Medicine. 8:55-61. 
53. Shyr, M.H., Tsai, T.H., Yang, C.H., Chen, H.M., Ng, H.F., Tan, P.P.C. (1997) Propofol anesthesia increases dopamine and serotonin actives at the somatosensory cortex in rats: a microdialysis. Anesthesia Analgesia. 84:1344-1348. (SCI)
54. Tsai, T.H.*, Matthews, K., Dalley, J.W. (1997) Determination of glutamate in rat brain microdialysates by microbore liquid chromatography with electrochemical detection. Journal of Liquid Chromatography. 20:3039-3047. (SCI)
55. Tsai, T.H.*, Hong, C.Y., Chen, C.F. (1997) Analysis of active ingredients in medicine herbs with high-performance liquid chromatography and related technologies: a review. Journal of Food and Drug Analysis. 5:303-317. (SCI)
56. Chang, C.C., Huang, H.C., Tsai, T.H., Chen, C.F. (1997) Determination of tetrandrine with high-performance liquid chromatography and its application to pharmacokinetic study in rats. Journal of Chinese Medicine. 8:229-236.
57. Wu, Y.S., Ho, W.M., Tsai, T.H., Yang, L.L., Kuo, J.S., Cheng, F.C. (1997) Monitoring of blood catecholamines by microdialysis and microbore liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 16:77-85. (SCI)
58. Peng, H.W., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1997) Validation of liquid chromatographic method in herbal medicine analysis. Journal of Chinese Medicine. 8:237-244.
59. Tsai, T.H.*, Chen, C.F. (1997) HPLC assessment of esculetin glucuronidation. Chinese pharmaceutical Journal. 49:321-324.
60. Peng, H.W., Cheng, F.C., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1998) Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography. Journal of Chromatography B. 714:369-374. (SCI)
61. Huang, C.T., Chen, K.C., Chen, C.F., Tsai, T.H.* (1998) Simultaneous measurement of blood and brain microdialysates of granisetron in rat by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B. 716:251-255. (SCI)
62. Peng, H.W., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1998) Glucuronidation of naringenin in rat. Planta Medica. 64:779. (SCI)
63. Tsai, T.H.*, Cheng, F.C., Hung, L.C., Chen, C.F. (1998) On-line microdialysis coupled with microbore liquid chromatography to measure chloramphenicol and its glucuronide in rat blood. Journal of Chromatography B. 720:165-169. (SCI)
64. Cheng, F.C., Tsai, T.H.*, Wu, Y.S., Kuo, J.S., Chen, C.F. (1999) Pharmacokinetic and pharmacodynamic analyses of trazodone in rat striatum by in vivo microdialysis. Journal of Pharmaceutical and Biomedical Analysis. 19:293-300. (SCI)
65. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Measurement and pharmacokinetic study of tetramethylpyrazine in rat blood and its regional brain tissue by high-performance liquid chromatography. Journal of Chromatography B. 724: 303-309. (SCI)
66. Dalley J.M., Thomas, K.L., Howes, S.R., Tsai, T.H., Aparicio-Legarza, M.I., Reynolds, G.P., Everitt, B.J., Robbins, T.W. (1999) Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens. European Journal of Neuroscience. 11:1265-1274. (SCI)
67. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Pharmacokinetic study of granisetron in rat blood and brain by microdialysis. Life Sciences. 64:1921-1931. (SCI)
68. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Regional brain distribution of tetramethylpyrazine in rat. Journal of Chinese Medicine. 10:117-123. 
69. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Pharmacokinetics and brain regional distribution of caffeine in rats. Journal of Chinese Medicine. 10:125-133.
70. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Determination of caffeine content in the tea and coffee. Journal of Chinese Medicine. 10:135-141.
71. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Measurement and pharmacokinetic study of unbound tropisetron in rat blood by microdialysis with high-performance liquid chromatography. International Journal of Pharmaceutics. 182:237-242. (SCI)
72. Tsai, T.H.*, Chen, Y.F., Chen, I.F., Chen, C.F. (1999) Measurement of unbound caffeic acid in rat blood by on-line microdialysis coupled with liquid chromatography and its application to pharmacokinetic studies. Journal of Chromatography B. 729:119-125. (SCI)
73. Tsai, T.H.*, Hung, L.C., Chen, C.F. (1999) Biliary excretion of chloramphenicol and chloramphenicol glucuronide in rat by microdialysis. Journal of Pharmacy and Pharmacology. 51:911-915. (SCI)
74. Tsai, T.H.*, Huang, C.T., Shum, A.Y.C., Chen, C.F. (1999) Pharmacokinetic and biliary excretion study of esculetin by microdialysis in rat. Life Sciences. 65:1647-1655. (SCI)
75. Tsai, T.H.*, Tsai, T.R., Chen, Y.F., Chou, C.J., Chen, C.F. (1999) Determination of unbound 20(S)-camptothecin in rat bile by on-line microdialysis coupled to microbore liquid chromatography with fluorescence detection. Journal of Chromatography B. 732:221-225. (SCI)
76. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Determination of tetramethylpyrazine in the herbs of chuanxiong and yujin by high-performance liquid chromatography. Journal of Chinese Medicine. 10:205-212.
77. Tsai, T.H.*, Hung, L.C., Shum, A.Y.C., Chen, C.F. (1999) Pharmacokinetic study of unbound chloramphenicol in rat blood and brain by microdialysis. Chinese Pharmaceutical Journal. 51:287-298.
78. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Biliary excretion of granisetron by microdialysis coupled to HPLC with fluorescence detection. Journal of Liquid Chromatography and Related Technologies. 22:2815-2823. (SCI)
79. Tsai, T.H.*, Cheng, F.C., Hung, L.C. Chen, C.F. (1999) Measurement of hydroxyl radical in rat blood vessels by microbore liquid chromatography and electrochemical detection: a microdialysis study. Journal of Chromatography B. 734:277-283. (SCI)
80. Tsai, T.H.*, Cheng, F.C., Chen, K.C., Chen, Y.F. Chen, C.F. (1999) Simultaneous measurement of cefuroxime in rat blood and brain by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 735:25-31. (SCI)
81. Tsai, T.H.*, Cheng, F.C., Hung, L.C., Chen, C.F. (1999) Determination of unbound ceftriaxone in rat blood by on-line microdialysis and microbore liquid chromatography. International Journal of Pharmaceutics. 193:21-26. (SCI)
82. Tsai, T.R., Cheng, F.C., Hung, L.C., Chen, C.F., Tsai, T.H.* (1999) Measurement of cefmetazole in rat blood by microdialysis coupled to microbore liquid chromatography: a pharmacokinetic application. Journal of Chromatography B. 736:129-134. (SCI)
83. Tsai, T.H.*, Shum, A.Y.C., Chen, C.F. (2000) Enterohepatic circulation of chloramphenicol and its glucuronide in the rat by microdialysis using a hepato-duodenal shunt. Life Sciences. 66:363-370. (SCI)
84. Tsai, T.H.*, Chen, Y.F., Chou, C.J., Chen, C.F. (2000) Measurement and pharmacokinetics unbound 20(S)-camptothecin in rat blood and brain by microdialysis coupled to microbore liquid chromatography with fluorescence detection. Journal of Chromatography A. 870:221-226. (SCI)
85. Cheng, F.C., Yang, L.L., Yang, D.Y., Tsai, T.H., Lee, C.W., Chen, S.H. (2000) Monitoring of extracellular pyruvate, lactic acid, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. J. Chromatography A. 870:389-394. (SCI)
86. Cheng, F.C., Kuo, J.S., Huang, H.M., Yang, D.Y., Wu, T.F., Tsai, T.H. (2000) Determination of catecholamines in pheochromocytoma cells culture medium by microdialysis - microbore liquid chromatography. Journal of Chromatography A. 870:405-411. (SCI)
87. Tsai, T.H.*, Chen, Y.F., Shum, A.Y.C., Chen, C.F. (2000) Determination of chlorogenic acid in rat blood by microdialysis coupled with microbore liquid chromatography in pharmacokinetic application. Journal of Chromatography A. 870:443-448. (SCI)
88. Tsai, T.H.*, Chen, Y.F., Chen, K.C., Shum, A.Y.C., Chen, C.F. (2000) Concurrent quantification and pharmacokinetic analysis of cefotaxime in rat blood and brain by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 738:75-81. (SCI)
89. Tsai, T.H.*, Tsai, T.R., Chen, Y.F. Chen, C.F. (2000) Determination and pharmacokinetic study of unbound cefoxitin in rat blood and brain with on-line microdialysis and microbore liquid chromatography. Analytica Chimica Acta. 412:13-18. (SCI)
90. Tsai, T.H.*, Hung, L.C., Chang, Y.L., Shum, A.Y.C., Chen, C.F. (2000) Simultaneous blood and brain sampling of cephalexin in the rat by microdialysis and microbore liquid chromatography: application to pharmacokinetics studies. Journal of Chromatography B. 740:203-209. (SCI)
91. Chang, Y.L., Chen, Y.F., Chen, C.F., Tsai, T.H.* (2000) Determination of unbound cephalothin in rat blood by on-line microdialysis and microbore liquid chromatography. Journal of Chromatography B. 742:125-130. (SCI)
92. Tsai, T.H.*, Chen, Y.F. (2000) Simultaneous blood and brain sampling and analysis of cefazolin in the rat by microdialysis and microbore liquid chromatography. Biomedical Chromatography. 14:274-278. (SCI)
93. Tsai, T.H.*, Tung, H.H., Hung, L.C., Cheng, F.C., Chen, C.F. (2000) Measurement of cimetidine in rat blood by microdialysis and liquid chromatography: a pharmacokinetic application. Journal of Liquid Chromatography and Related Technologies. 23:1599-1608. (SCI)
94. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, Y.F., Chen, C.F., Cheng, F.C., Tsai, T.H.* (2000) Simultaneous determination of unbound cefoperazone in rat blood and brain using microdialysis. Journal of Pharmacy and Pharmacology. 52:963-968. (SCI)
95. Tsai, T.H.* (2000) Separation methods used in choline and acetylcholine assay. Journal of Chromatography B. 747:111-122. (SCI)
96. Tsai, T.H.*, Liu, S.C., Ho, L.K., Chen, C.F. (2000) Determination of unbound ampicillin in rat blood by microdialysis and liquid chromatography. Analytical Letters. 33: 3213-3224. (SCI)
97. Tsai, T.H.*, Chen, Y.F. (2000) Determination of unbound hesperetin in rat blood and brain by microdialysis coupled to microbore liquid chromatography. Journal of Food and Drug Analysis. 8: 331-336. (SCI)
98. Tsai, T.H.*, Kao, H.Y., Chen, C.F. (2001) Measurement and pharmacokinetic analysis of unbound ceftazidime in rat blood by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 750: 93-98. (SCI)
99. Yeh, P.H., Lee, C.H., Cheng, F.C., Tsai, T.H.* (2001) Determination of unbound cefamandole in rat blood by microdialysis and microbore liquid chromatography. Biomedical Chromatography. 15: 14-17. (SCI)
100. Tsai, T.H.* (2001) Effect of ivermectin on the disposition of amoxicillin in rat blood and brain using microdialysis. Analytica Chimica Acta. 431:279-285. (SCI)
101. Matthews, K., Dalley, J., Matthews, C., Tsai, T.H., Robbins, T.W. (2001) Periodic maternal separation of neonatal rats produces regionally and gender specific effects on biogenic amine content in post-mortem adult brain. Synapse. 40: 1-10. (SCI)
102. Tsai, T.H.*, Liang, C.C. (2001) Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis. International Journal of Pharmaceutics. 216: 61-66. (SCI)
103. Wu, Y.S., Tsai, T.H., Wu, T.F., Cheng, F.C. (2001) Determination of pyruvate and lactate in primary liver cell culture medium during hypoxia by on-line microdialysis/liquid chromatography. Journal of Chromatography A. 913: 341-347. (SCI)
104. Yang, D.Y., Tsai, T.H., Cheng, C.H., Lee, C.W., Chen, S.H., Cheng, F.C. (2001) Simultaneous monitoring of extracellular glucose, pyruvate, lactate and glutamate in gerbil cortex during focal cerebral ischemia by dual-probe microdialysis. Journal of Chromatography A. 913: 349-354. (SCI)
105. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2001) Determination and pharmacokinetic study of unbound cefepime in rat bile and liquid chromatography with on-line microdialysis. Journal of Chromatography A. 914: 77-82. (SCI)
106. Tsai, T.H., Cheng, F.C., Chen, Y.F., Chen, C.F. (2001) On-line microdialysis coupled with microbore liquid chromatography with ultraviolet detection for continuous monitoring of free cefsulodin in rat blood. Journal of Chromatography A. 914: 83-87. (SCI)
107. Tsai, T.H.* (2001) Pharmacokinetics of pefloxacin and its interaction with cyclosporin A, a P-glycoprotein modulator, in rat blood, brain and bile, using simultaneous microdialysis. British Journal of Pharmacology. 132: 1310-1316. (SCI)
108. Tsai, T.H.*, Kao, H.Y., Chen, C.F. (2001) Measurement and pharmacokinetic analysis of unbound cephaloridine in rat blood by on-line microdialysis and microbore liquid chromatography. Biomedical Chromatography. 15: 79-82. (SCI)
109. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2001) Effect of cyclosporine, P-glycoprotein inhibitor, on the pharmacokinetics of cefepime in rat blood and brain: a microdialysis study. Life Sciences. 69: 191-199.(SCI)
110. Tsai, T.H.*, Wang, L.H., Hung, L.C., Tseng, T.Y., Chen, C.F. (2001) An animal brain microdialysis model for acupuncture study. Journal of Chinese Medicine. 12:129-144.
111. Kau, Y.C., Wong, K.M., Shyr, M.H., Lee, Y.H., Tsai, T.H.* (2001) Simultaneous determination of unbound ropivacaine in rat blood and brain using microdialysis. Journal of Chromatography B. 760:107-112. (SCI)
112. Tsai, T.H.*, Peng, H.W., Chen, C.F. (2001) Enterohepatic circulation of naringenin using paired-rats model. Chinese Pharmaceutical Journal. 53:55-61.
113. Tsai, T.H.* (2001) Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity. Journal of Chromatography B. 764:27-48. (SCI)
114. Tsai, T.H.*, Wu, J.W. (2001) Pharmacokinetics of ciprofloxacin in the rat and its interaction with cyclosporin A: a microdialysis study. Analytica Chimica Acta. 448:195-199. (SCI)
115. Tsai, T.H.*, Lee, C.H., Yeh, P.H. (2001) Effect of cyclosporin A, a P-glycoprotein modulator, on the pharmacokinetics of camptothecin using microdialysis. British Journal of Pharmacology. 134:1245-1252. (SCI)
116. Chen, Y.J., Shiao, M.S., Hsu, M.L., Tsai, T.H., Wang, S.Y. (2001) The effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells. Journal of Agriculture Food and Chemistry. 49:5615-5619. (SCI)
117. Cheng, F.C., Ho, Y.F., Hung, L.C., Chen, C.F., Tsai, T.H.* (2002) Determination and pharmacokinetic profile of omeprazole in rat blood, brain and bile by microdialysis and high-performance liquid chromatography. Journal of Chromatography A. 949:35-42. (SCI)
118. Liu, S.C., Tsai, T.H.* (2002) Determination of diclofenac in rat bile and its interaction with cyclosporin A using on-line microdialysis coupled to liquid chromatography. Journal of Chromatography B. 769:351-356. (SCI)
119. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2002) Determination and pharmacokinetic study of meropenem in rat bile with on-line microdialysis and liquid chromatography. Journal of Chromatography A. 961:119-124. (SCI)
120. Tsai, T.R., Tseng, T.Y., Chen, C.F., Tsai, T.H.* (2002) Determination and identification of geniposide contained in Gardenia jasminoides, and in two preparations of mixed traditional Chinese medicines. Journal of Chromatography A. 961:83-88. (SCI)
121. Tsai, P.L., Tsai, T.H.* (2002) Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to liquid chromatography. Journal of Chromatography A. 961:125-130. (SCI)
122. Cheng, F.C., Tsai, T.R., Chen, Y.F., Hung, L.C., Tsai, T.H.* (2002) Determination of levofloxacin in rat blood and bile by microdialysis and high-performance liquid chromatography: a pharmacokinetic study. Journal of Chromatography A. 961:131-136. (SCI)
123. Lee, C.H., Yeh, P.H., Tsai, T.H.* (2002) Hepatobiliary excretion of fluconazole and its interaction with cyclosporin A in rat blood and bile using simultaneous microdialysis. International Journal of Pharmaceutics. 241:367-373 (SCI)
124. Yang, S.E., Hsieh, M.T., Tsai, T.H., Hsu, S.L. (2002) Down-modulation of Bcl-XL, release cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human sequamous lung cancer CH27 cells. Biochemical Pharmacology. 63:1641-1651. (SCI)
125. Cheng, F.C., Jen, C.F., Tsai, T.H.* (2002) Hydroxyl radical in the living systems and its separation methods. Journal of Chromatography B. 781:481-495. (SCI)
126. Tsai, P.L., Tsai, T.H.* (2002) High-performance liquid chromatographic determination of berberine contained in medicinal herbs and a related traditional Chinese medicine. Analytical Letters. 35:2459-2470. (SCI)
127. Tsai, T.H.* (2002) Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin A, a P-glycoprotein modulator. Journal of Agriculture and Food Chemistry. 50:6669-6674. (SCI)
128. Tsai, T.H.*, Liu, S.C., Tsai, P.L., Ho, L.K., Shum, A.Y.C., Chen, C.F. (2002) Pharmacokinetics of baicalein and its interaction with P-glycoprotein inhibitor, cyclosporin A, in the rat: a microdialysis study. British Journal of Pharmacology. 137:1314-1320. (SCI)
129. Yang, S.E., Hsieh, M.T. Hsieh, Tsai, T.H., Hsu, S.L. (2003) Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. British Journal of Pharmacology. 138: 193-201. (SCI)
130. Tsai, T.H.*, Chen, Y.F., Chen, C.F. (2003) Pharmacokinetics of metronidazole in rat blood, brain, and bile studied using microdialysis. Journal of Chromatography A. 987: 277 - 282. (SCI)
131. Lai, L., Lin, L.C., Lin, J.H., Tsai, T.H.* (2003) Pharmacokinetics of mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography A. 987:367-374. (SCI)
132. Tsai, T.H.*, Wu, J.W. (2003) Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein and cytochrome P450 using microdialysis. Life Sciences. 72: 2413-2426. (SCI)
133. Wang, G.J., Tseng, H.W., Chou, C.J., Tsai, T.H., Chen, C.T., Lu, M.K. (2003) The vasorelaxation of Antrodia camphorate mycelia: involvement of endothelial Ca2+-NO-cGMP pathway. Life Sciences. 73:2769-2783. (SCI)
134. Tsai, T.H.* (2003) Assaying protein unbound drugs using microdialysis techniques. Journal of Chromatography B. 797:161-173. (SCI)
135. Tsai, T.H.*, Liu, M.C. (2004) Determination and brain distribution of theophylline in rat blood and brain using microdialysis and microbore liquid chromatography. Journal of Chromatography A. 1032:97-101. (SCI)
136. Lin, L.C., Hung, L.C., Tsai, T.H.* (2004) Determination of (-)-epigallocatechin gallate in rat blood using microdialysis coupled with liquid chromatography. Journal of Chromatography A. 1032:125-128. (SCI)
137. Tsai, P.L., Tsai, T.H.* (2004) Hepatobiliary excretion of berberine. Drug Metabolism and Disposition. 32:405-412. (SCI)
138. Tsai, T.H.*, Liu, M.C. (2004) Determination of extracellular hesperidin in blood and bile of anaesthetized rats by microdialysis with high-performance liquid chromatography: a pharmacokinetic application. Journal of Chromatography B. 806:161-166. (SCI)
139. Tseng, T.Y., Tsai, T.H.* (2004) Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence by the acupuncture. Analytica Chimica Acta. 517:47-52. (SCI)
140. Wu, J.W., Shih, H.H., Wang, S.C., Tsai, T.H.* (2004) Determination and pharmacokinetic profile of pyrazinamide in rat blood, brain and bile using microdialysis coupled with high-performance liquid chromatography and verified by tandem mass spectrometry. Analytica Chimica Acta. 522:231-239 (SCI)
141. Tsai, P.L., Tsai, T.H.* (2004) Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Planta Medica 70:1069-1074 (SCI)
142. Chang, C.H., Fan, K.H., Chen, T.J., Hsu, W.C., Jan, M.L., Tsai, T.H., Kao, P.F., Chen, C.F., Fu, Y.K., Lee, T.W. (2004) Dynamic evaluation of [18F]FDG uptake in fibrosarcoma-bearing mouse model: by microPET and whole body autoradiography. Journal of the Formosan Medical Association. 103:867-881 (SCI)
143. Wang, S.C., Tseng, T.Y., Huang, C.M., Tsai, T.H.* (2004) Gardenia herbal active constituents – Applicable separation procedures. Journal of Chromatography B. 812:193-202. (SCI)
144. Fang, J.Y., Tsai, T.H., Hung, C.F., Wong, W.W. (2004) Development and Evaluation of the Essential Oil from Magnolia fargesii for Enhancing the Transdermal Absorption of Theophylline and (+)-Catechin. Journal of Pharmacy and Pharmacology. 56:1493-500. (SCI)
145. Huang, S.M., Tsai, D.R., Tsai, T.H.* (2005) Measurement of unbound ranitidine in blood and bile of anesthetized rats using microdialysis coupled to liquid chromatography and its pharmacokinetic application. Journal of Chromatography A 1073:297-302 (SCI)
146. Lin, L.C., Yang, K.Y., Chen, Y.F., Wang, S.C., Tsai, T.H.* (2005) Measurement of daphnoretin in plasma of freely moving rat by liquid chromatography. Journal of Chromatography A 1073:285-289 (SCI)
147. Huang, Y.J., Liao, J.F., Tsai, T.H.* (2005) Concurrent determination of thalidomide in rat blood, brain and bile using multiple microdialysis coupled to liquid chromatography. Biomedical Chromatography. 19:488-493 (SCI)
148. Ueng, Y.F., Tsai, T.H., Don, M.J., Chen, R.M., Chen, T.L. (2005) Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa. Journal of Pharmacy and Pharmacology 57:227-232 (SCI)
149. Tsai, T.H.* (2005) Concurrent measurement of unbound genistein in the blood, brain and bile of anesthetized rats using microdialysis and its pharmacokinetic application. Journal of Chromatography A 1073:317-322 (SCI)
150. Chuang, H.N., Wang, J.Y., Chiu, J.H., Tsai, T.H., Yeh, S.F., Fu, S.L., Lui, W.Y., Wu, C.W. (2005) Enhancing Effects of Scutellaria baicalensis and Some of its Constituents on TGF-β1 Gene Expression in RAW 264.7 Murine Macrophage Cell Line. Planta Medica. 71:440-445. (SCI)
151. Chen, Y.F., Chang, C.H., Wang, S.C., Tsai, T.H.* (2005) Measurement of protein-unbound cocaine in blood, brain, and bile of anesthetized rats using microdialysis coupled with liquid chromatography and verified by tandem mass spectrometry. Biomedical Chromatography. 19:402-408. (SCI)
152. Chen, Y.J., Shieh, C.J., Tsai, T.H., Kuo, C.D., Ho, L.T., Liu, T.Y., Liao, H.F. (2005) Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anti-Cancer Drugs. 16:293-299. (SCI)
153. Juan, Y.P., Tsai, T.H.* (2005) Measurement and pharmacokinetics of vincamine in rat blood and brain using microdialysis. Journal of Chromatography A. 1088:146-151. (SCI)
154. Chang, C.H., Tsai, L.C., Chen, S.T., Yuan, C.C., Hung, M.W., Hsieh, B.T., Chao, P.L., Tsai, T.H., Lee, T.W. (2005) Radioimmunotherapy and apoptotic induction on Ck19 overexpressing human cervical carcinoma cells with Re-188-mAbCx-99. Anticancer Research. 25:2719-2728. (SCI)
155. Chang, Y.L., Tsai, P.L., Chou, Y.C., Tien, J.H., Tsai, T.H.* (2005) Simultaneous determination of nicotine and its metabolite, cotinine, in rat blood and brain tissue using microdialysis coupled with HPLC-UV: a pharmacokinetic application. Journal of Chromatography A. 1088:152-157. (SCI)
156. Wang, J.Y., Chiu, J.H., Tsai, T.H., Tsou, A.P., Hu, C.P., Chi, C.W., Yeh, S.F., Lui, W.Y., Wu, C.W., Chou, C.K., (2005) Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice. International Journal of Molecular Medicine. 16:221-231. (SCI)
157. Chen, Y.F., Jaw, I., Shiao, M.S., Tsai, T.H.* (2005) Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatography. Journal of Chromatography A. 1088:140-145. (SCI)
158. Tsai, T.H.*, Chang, C.H., Lin, L.C. (2005) Effect of Evodia rutaecarpa on the pharmacokinetics of caffeine. Planta Medica. 71:640-645. (SCI)
159. Tsai, P.L., Tsai, T.H.* (2005) Measurement of unbound pravastatin in rat blood and bile on the perspective of hepatobiliary excretion and its interaction with cyclosporin A and berberine. Analytica Chimica Acta. 548:33-40 (SCI)
160. Hsieh, Y.J., Lin, L.C., Tsai, T.H.* (2005) Identification and determination of plumbagin from the roots of Plumbago zeylanica extract by liquid chromatography with tandem mass spectrometry. Journal of Chromatography A. 1083:141-145. (SCI)
161. Jan, W.C., Lin, L.C., Chou, C.J., Tsai, T.H.* (2005) Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats. Journal of Ethnopharmacology. 102:440-445. (SCI)
162. Chen, Y.J., Liao, H.F., Tsai, T.H., Wang, S.Y., Shiao, M.S. (2005) Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. International Journal of Radiation Oncology Biology Physics. 63:1252-1261. (SCI)
163. Chang, C.H., Jan, M.L., Fan, K.H., Wang, H.E., Tsai, T.H., Chen, C.F., Fu, Y.K., Lee, T.W. (2006) Longitudinal Evaluation of Tumor Metastasis by an FDG-microPET/microCT Dual-Imaging Modality in a Lung Carcinoma-Bearing Mouse Model. Anticancer Research. 26:159-166. (SCI)
164. Chang, C.H., Wu, S.Y., Wang, H.E., Fan, K.H., Tsai, T.H., Lee, T.W., Chang, S.R., Liu, R.S., Fu, Y.K. (2006) Comparative evaluation of FET and FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Research. 26:917-926. (SCI)
165. Shyr, M.H., Tsai, T.H., Lin, L.C. (2006) Isolation and Structures of Rossicasin A, B and Rosicaside F, new phenylpropanoid Glycosides from Boschniakia rossica Chemical and Pharmaceutical Bulletin. 54:252-254. (SCI)
166. Wang, S.C., Ho, L.K., Yen, J.C., Chen, Y.F., Tsai, T.H.* (2006) An automated blood sampling system to measure lovastatin level in plasma and feces of freely moving rat and verified by LC-MS/MS. Biomedical Chromatography. 20:911-916. (SCI)
167. Shyr, M.H., Lin, L.C. Lin, T.Y. Lin, Tsai, T.H.* (2006) Determination and pharmacokinetics of evodiamine in the plasma and feces of conscious rats. Analytica Chimica Acta. 558:16-21. (SCI)
168. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2006) Determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometry. Biomedical Chromatography. 20:1076-1081. (SCI)
169. Hsieh, C.L., Cheng, C.Y., Tsai, T.H., Lin, I.H., Liu, C.H., Chiang, S.Y., Lin, J.G., Lao, C.J., Tang, N.Y. (2006) Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. Journal of Ethnopharmacology. 106:208-215. (SCI)
170. Shyr, M.H., Lin, L.C., Chang, C.H., Wu, Y.T., Hsieh, Y.J., Tsai, T.H.* (2006) Hepatobiliary excretion and brain distribution of caffeine in rat using microdialysis. Analytica Chimica Acta. 566:265-270. (SCI) 
171. Wang, J.Y., Chuang, H.N., Chiu, J.H., Fu, S.L., Tsai, T.H., Tsou, A.P., Hu, C.P., Chi, C.W., Yeh, S.F., Lui, W.Y., Wu, C.W., Chou, C.K. (2006) Effect of Scutellaria baicalensis Georgi on macrophage hepatocyte interaction through cytokines related to growth control of murine hepatocytes. Experimental Biology and Medicine. 231: 444-455. (SCI)
172. Chiou, S.H., Ku, H.H., Tsai, T.H., Lin, H.L., Chen, L.H., Chien, C.S., Ho, L.L.T., Lee, C.H., Chang, Y.L., (2006) Moclobemide (MB) Up-regulated Bcl-2 Expression and Induced Neural Stem Cell Differentiation into Serotoninergic Neuron via extracellular-regulated kinase (ERK) Pathway. British Journal of Pharmacology. 148:587-598. (SCI)
173. Jan, W.C., Lin, L.C., M.J. Don, Chen, C.F., Tsai, T.H.* (2006) Elimination of rutaecarpine and its metabolites in rat feces and urine measured by liquid chromatography. Biomedical Chromatography. 20:1163-1171. (SCI)
174. Lin, L.C., Tsai, T.H.* (2006) Pharmacokinetics brain distribution of unbound levamisole in the anesthetized rats using microdialysis and microbore column liquid chromatography. Analytica Chimica Acta. 569:145-150. (SCI)
175. Chen, Y.J., Lin, L.C., Shyr, M.H., Tsai, T.H.* (2006) Pharmacokinetics of unbound linezolid in the blood and the mechanism of hepatobiliary excretion in the rat. Analytica Chimica Acta. 570:59-64. (SCI)
176. Lin, L.C., Shen, C.C., Shen, Y.C., Tsai, T.H.* (2006) Anti-inflammatory neolignans from Piper kadsura. Journal of Natural Products. 69:842-844. (SCI)
177. Hsieh, Y.J., Lin, L.C., Tsai, T.H.* (2006) Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry. Journal of Chromatography B. 844:1-5. (SCI)
178. Wu, Y.T., Chen, Y.F., Hsieh, Y.J., Jaw, I., Shiao, M.S., Tsai, T.H.* (2006) Bioavailability of salvianolic acid B in conscious and freely moving rats. International Journal of Pharmaceutics. 326:25-31. (SCI)
179. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2006) Determination of acteoside in Cistanche deserticola and Boschniakia rossica and its pharmacokinetics in freely-moving rats using LC-MS/MS. Journal of Chromatography B. 844:89-95. (SCI)
180. Chen, S.J., Kao, C.L., Chang, Y.L., Yen, C.J., Shui, J.W., Chien, C.S., Chen, I.L., Tsai, T.H., Ku, H.H., Chiou, S.H. (2007) Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through Bcl-2. Current Neurovascular Research. 4:19-29 (SCI)
181. Fang, J.Y., Tsai, T.H., Lin, Y.Y., Wong, W.W., Wang, M.N., Huang, J.F. (2007) Transdermal delivery of tea catechins and theophylline enhanced by terpenes: a mechanistic study. Biological and Pharmaceutical Bulletin. 30: 343-349. (SCI)
182. Lin, L.C., Wang, M.N., Tseng, T.Y., Sung, J.S., Tsai, T.H.* (2007) Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution. Journal of Agriculture and Food Chemistry. 55: 1517-1524. (SCI)
183. Chiou, S.H., Ku, H.H., Chen, M., Huang, Y.L., Tsai, Y.J., Chen, L.S., Chung, C.F., Chiu, J.H., Tsai, T.H.* (2007) Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis. Analytical Biochemistry. 363:46-57. (SCI)
184. Wang, S.C., Huang, C.M., Tsai, T.H. (2007) Determinations of geniposide using LC/MS/MS methods via forming ammonium and acetate adducts. Microchemical Journal. 86:174-182. (SCI)
185. Lin, H.T., Kao, C.L., Lee, K.H., Chang, Y.L., Chiou, S.H., Tsai, F.T., Tsai, T.H., Sheu, D.C., Ho, L.L.T., Ku, H.H. (2007) Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method. World Journal of Gastroenterology. 13:1672-1679.
186. Chang, C.M., Kao, C.L., Chang, Y.L., Yang, M.J., Chen, Y.C., Sung, B.L., Tsai, T.H., Chao, K.C., Chiou, S.H., Ku, H.H. (2007) Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells. Biochemical and Biophysical Research Communications. 347:414-420 (SCI)
187. Huang, Y.T., Cheng, C.J., Lai, T.F., Tsai, T.R., Tsai, T.H., Chuo, W.H., Cham, T.M. (2007) An investigation of acetylcholine released in skeletal muscle and protein unbound drug released in blood based on the pyridostigmine bromide (pretreatment drug) sustained-release pellets by microdialysis technique in the rabbit model. Neuroscience Letter. 416:302-306. (SCI)
188. Yang, K.Y., Lin, L.C., Tseng, T.Y., Wang, S.C., Tsai, T.H.* (2007) Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. Journal of Chromatography B. 853:183-189. (SCI)
189. Lin, L.C., Chen, Y.F., Tsai, T.R., Tsai, T.H.* (2007) Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Analytica Chimica Acta. 590:173-179. (SCI)
190. Wu, Y.T., Tsai, T.R., Lin, L.C., Tsai, T.H.* (2007) Liquid chromatographic method with amperometric detection to determine acteoside in rat blood and brain microdialysates and its application to pharmacokinetic study. Journal of Chromatography B. 853:281-286. (SCI)
191. Chang, Y.L., Chiou, S.H., Chou, Y.C., Yen, C.J., Tsai, T.H.* (2007) Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 45: 158–163. (SCI)
192. Chang, C.H., Hsu, W.C., Wang, C.Y., Jan, M.L., Tsai, T.H., Lee, T.W., Lynn, S.G., Yeh, C.H., Chang, T.J. (2007) Longitudinal microSPECT/CT imaging and Pharmacokinetics of Synthetic Luteinizing Hormone Releasing Hormone (LHRH) vaccine in rats. Anticancer Research. 27:3251-3258. (SCI)
193. Wang, G.J., Tsai, T.H., Lin, L.C. (2007) New Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum. Phytochemistry. 68: 2455–2464. (SCI)
194. Wu, J.W., Tsai, T.H.* (2007) Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid. Drug Metabolism and Disposition. 35:1603-1610. (SCI)
195. Wu, J.W., Lin, L.C., Hung, S.C., Chi, C.W., Tsai, T.H.* (2007) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. Journal of Pharmaceutical and Biomedical Analysis. 45:635-641. (SCI)
196. Lin, C.L., Lin, S.J., Huang, W.J., Ku, Y.L., Tsai, T.H., Hsu, F.L. (2007) Novel ent-Beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina. Planta Medica. 73: 1581-1587. (SCI)
197. Ho, Y.F., Lai, M.Y., Yu, S.Y., Huang, T.K., Shai, W.C., Tsai, T.H., Lin, C.Y. (2008) Application of rat in situ single-pass intestinal perfusion in the evaluation of pre-systemic extraction of indinavir under different perfusion rates. Journal of the Formosan Medical Association. 107:37–45. (SCI)
198. Peng, C.H., Chiou, S.H., Chen, S.J., Chou, Y.C., Ku, H.H., Cheng, C.K., Yen, C.J., Tsai, T.H., Chang, Y.L., Kao, C.L. (2008) Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. European Neuropsychopharmacology. 18:128-140. (SCI)
199. Chen, Y.J., Huang, S.M., Liu, C.Y., Yeh, P.H., Tsai, T.H.* (2008) Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. International Journal of Pharmaceutics. 350:230-239. (SCI)
200. Hsieh, Y.J., Chang, C.H., Huang, S.P., Lin, C.W., Wang, M.N., Wu, Y.T., Chen, Y.J., Tsai, T.H.* (2008) Effects of the cyclosporin A on the brain distribution of doxorubicin in rats. International Journal of Pharmaceutics. 350:265-271. (SCI)
201. Wu, J.W., Lin, L.C., Hung, S.C., Lin, C.H., Chi, C.W., Tsai, T.H.* (2008) Hepatobiliary excretion of silibinin and liver cirrhosis induced by dimethylnitrosamine. Drug Metabolism and Disposition. 36:589-596. (SCI)
202. Tsai, T.H., Wang, G.J., Lin, L.C. (2008) Vasorelaxing alkaloids and flavonoids from Cassytha filiformis. Journal of Natural Products. 71:289-291. (SCI)
203 Fu, Y.S., Lin, Y.Y., Chou, S.C., Tsai, T.H., Kao, L.S., Hsu, S.Y., Cheng, F.C., Shih, Y.H., Cheng, H., Fu, Y.Y., Wang, J.Y. (2008) Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-encitotoxicity – potential therapeutic application for treatment of glioma. Neuro-Oncology. 10:139-152. (SCI)
204. Lee, Y.Y., Kao, C.L., Tsai, P.H., Tsai, T.H., Chiou, S.H., Wu, W.F., Ku, H.H., Wong, T.T. (2008) Caffeic acid phenethyl ester preferentially enhanced radiosensitizing and increased oxidative stress in medulloblastoma cell line. Childs Nervous System. 24:978-994. (SCI)
205. Hsu, C.H., Tsai, T.H., Kao, Y.H., Hwang, K.C., Tseng, T.Y., Chou, P. (2008) Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition. 27:363-370 (SCI)
206. Kapuriya, N., Kapuriya, K., Zhang, X., Chou, T.C., Kakadiya, R., Wu, Y.T., Tsai, T.H., Chen, Y.T., Lee, T.C., Shah, A., Naliapara, Y., Su, T.L. (2008) Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorganic and Medicinal Chemistry. 16:5413-5423. (SCI)
207. Chiou, S.H., Yu, C.C., Huang, C.Y., Lin, S.C., Liu, C.J., Tsai, T.H., Chou, S.H., Chien, C.S., Ku, H.H., Lo, J.F. (2008) Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research. 14:4085-4095. (SCI)
208. Lin, L.C., Wang, M.N., Tsai, T.H.* (2008) Herb-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and metabolite SN-38. Chemico-Biological Interactions. 174:177-182. (SCI)
209. Tsai, T.H., Lin, L.C. (2008) Phenolic glycosides and pyrrolidium alkaloids from Codonopsis tangshen. Chemical and Pharmaceutical Bulletin. 56:1546-1550. (SCI)
210. Lin, L.C., Chen, Y.F., Lee, W.C., Wu, Y.T., Tsai, T.H.* (2008) Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 48:909-917. (SCI)
211. Wang, S.C., Liao, H.J., Lee, W.C., Huang, C.M., Tsai, T.H. (2008) Using orthogonal array to obtain gradient liquid chromatography conditions of enhanced peak intensity to determine geniposide, genipin with electrospray tandem mass spectrometry. Journal of Chromatography A. 1212:68-75. (SCI) 
212. Kapuriya, N., Kapuriya, K., Dong, H., Zhang, X., Chou, T.C., Chen, Y.T., Lee, T.C., Lee, W.C., Tsai, T.H., Naliapara, Y., Su, T.L. (2009) Novel DNA-directed alkylating agents: Design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. Bioorganic and Medicinal Chemistry. 17:1264-1275. (SCI)
213. Huang, T.F., Chen, Y.T., Yang, T.H., Chen, L.L., Chiou, S.H., Tsai, T.H., Tsai, C.C., Chen, M.H., Ma, H.L., Hung, S.C. (2009) Isolation and characterization of mesenchymal stromal cells from human anterior cruciate ligament. Cytotherapy. 10:806-814. (SCI)
214. Wu, J.W., Lin, L.C., Tsai, T.H.* (2009) Drug-drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology. 121:185-193. (SCI)
215. Huang, S.P., Lin, L.C., Wu, Y.T., Tsai, T.H.* (2009) Pharmacokinetics of kadsurenone in rats using HPLC and microdialysis system. Journal of Chromatography B. 877:247-252. (SCI)
216. Liu, H.K., Tsai, T.H., Chang, T.T., Chou, C.J., Lin, L.C. (2009) Lanostane-triterpenoids from the fungus Phellinus gilvus. Phytochemistry. 70:558-563. (SCI)
217. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2009) Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection. Journal of Chromatography A. 1216:3501–3507. (SCI)
218. Chang, J.C., Lee, W.C., Lin, L.C., Tsai, T.H.* (2009) Distribution of blood-to-muscle for clenbuterol in rat using microdialysis. International Journal of Pharmaceutics. 372: 91-96.
219. Wu, Y.T., Huang, C.M., Lin, C.C., Ho, W.A., Lin, L.C., Chiu, T.F., Tarng, D.C., Lin, C.H., Tsai, T.H.* (2009) Determination of melamine in rat plasma, liver, kidney, spleen, bladder and brain by liquid chromatography tandem mass spectrometry. Journal of Chromatography A. 1216:7595-7601. (SCI)
220. Wang, G.J., Tsai, T.H., Chang, T.T., Chou, C.J., Lin, L.C. (2009) Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. Planta Medica. 75:1-6. (SCI)
221. Chen, W.L., Tsai, T.H., Huang, C.C., Chen, J.H., Kuo, C.D. (2009) Heart rate variability predicts short-term outcome for successfully resuscitated patients with out-of-hospital cardiac arrest. Resuscitation. 81:1114-1118. (SCI)
222. Ho, Y.F., Huang, D.K., Hsueh, W.C., Lai, M.Y., Yu, H.Y., Tsai, T.H. (2009) Effects of St. John's wort extract on indinavir pharmacokinetics in rats: Differentiation of intestinal and hepatic impacts. Life Sciences 85: 296–302. (SCI)
223. Chang, J.C., Wu, Y.T., Lee, W.C., Lin, L.C., Tsai, T.H.* (2009) Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats. Chemico-Biological Interactions. 182:227-232. (SCI)
224. Hsieh, C.H., Wei, M.C., Lee, H.Y., Hsiao, S.M., Chen, C.A., Wang, L.Y., Hsieh, Y.P., Tsai, T.H., Chen, Y.J., Shueng, P.W. (2009) Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical Tomothearapy. Radiation Oncology. 4:62. (SCI)
225. Chen, C.A., Chang, H.H., Kao, C.Y., Tsai, T.H., Chen, Y.J. (2009) Plumbagin, Isolated from Plumbago zeylanica, Induces Cell Death through Apoptosis in Human Pancreatic Cancer Cells. Pancreatology, 9:797-809. (SCI)
226. Chen, I.L., Tsai, Y.J., Huang, C.M., Tsai, T.H.* (2010) Pharmacokinetics of quercetin in rat plasma and lymph on a mesenteric lymphatic-cannulated model. Journal of Agriculture and Food Chemistry. 58:546-551. (SCI)
227. Wu, Y.T., Huang, C.M., Lin, C.C., Ho, W.A., Lin, L.C., Chiu, T.F., Tarng, D.C., Lin, C.H., Tsai, T.H.* (2010) Oral bioavailability, urinary excretion and organ distribution of melamine in Sprague–Dawley rats by high-performance liquid chromatography with tandem mass spectrometry. Journal of Agriculture and Food Chemistry. 58:108-111. (SCI)
228. Chen, C.C., Tsai, T.H., Huang, Z.R., Fang, J.Y. (2010) Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics. 74: 474–482. (SCI)
229. Chen, K.H., Hsu, C.C., Song, W.S., Huang, C.S., Tsai, C.C., Kuo, C.D., Hsu, H.S., Tsai, T.H., Tsai, C.Y., Woung, L.C., Chiou, S.H., Lu, K.H., Chen, Y.W. (2010). Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells. Childs Nervous System. 26:1605-1612. (SCI)
230. Chen, W.L., Tsai, T.H., Yang, C.C.H., Kuo, T.B.J (2010) Acute Effects of Ephedra on Autonomic Nervous Modulation in Healthy Young Adults. Clinical Pharmacological Therapy. 88(1):39-44. (SCI)
231. Chen, W.L., Tsai, T.H., Yang, C.C.H., Kuo, T.B.J. (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology. 130:563-568. (SCI)
232. Tsai, Y.J., Lin, L.C., Tsai, T.H.* (2010) Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. Journal of Agriculture and Food Chemistry. 58, 4638–4643. (SCI)
233. Hsieh, C.H., Hsieh, Y.J., Lin, C.Y., Tai, H.C., Huang, Y.C., Shueng, P.W., Lee, H.Y., Tsai, T.H.*, Chen, Y.J.* (2010) Abdominal Irradiation Modulates 5-Fluorouracil Pharmacokinetics. Journal of Translational Medicine. 8:29 (SCI)
234. Lee, W.C., Tsai, T.H.* (2010) Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application. International Journal of Pharmaceutics. 395, 78-83. (SCI)
235. Wu, Y.T., Kao, Y.L., Lin, L.C., Tsai, T.H.* (2010) Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats. International Journal of Pharmaceutics. 396, 127–133. (SCI)
236. Chien, C.F., Wu, Y.T., Lee, W.C., Lin, L.C., Tsai, T.H.* (2010) Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chemico-Biological Interactions. 184: 458-465. (SCI)
237. Tsai, T.H.*, Chen, I.L. (2010) Rebuttal to a comment on lymphatic absorptions of quercetin and rutin in the rat and their pharmacokinetics in systemic plasma. Journal of Agriculture and Food Chemistry. 58, 8468-8469. (SCI)
238. Lin, C.C., Wu, Y.T., Yen, J.C., Chiang, C.J., Tsuang, Y.H., Tsai, T.H.* (2010) In vitro and in vivo models to measure ceftriaxone distribution into the rat tail intervertebral disc. Analytical Sciences. 26, 979-982. (SCI)
239. Tsai, T.H., Liu, Y.C., Lin, L.C. (2010). Flavonoids from Taxillus theifer. Journal of Food and Drug Analysis. 18: 256-262. (SCI)
240. Wu, Y.T., Lin, C.W., Lin, L.C., Chiu, A.W., Chen, K.K., Tsai, T.H.* (2010) Analysis of biliary excretion of icariin in rats. Journal of Agriculture and Food Chemistry. 58(18):9905-9911. (SCI)
241. Wang, K.L., Yang, Y.C., Lai, C